To interpret the results of genomic sequencing requires careful analysis of each genome variant discovered and what it might mean. The variant and gene curation teams at Geisinger are dedicated to accurately interpreting complex genomic data into meaningful knowledge for numerous research and clinical efforts. Additionally, leaders of Geisinger's Autism & Developmental Medicine Institute (ADMI) and Genomic Medicine Institute (GMI) are at the forefront of national and international efforts to standardize and streamline variant and gene curation processes. Through collaborative partnerships funded by the NIH, such as the Clinical Genome Resource (ClinGen) and the Electronic Medical Records and Genomics (eMERGE) Network, and other grants, members of our team are driving innovative efforts and helping to define high standards for all curation efforts. Geisinger remains a leader in these efforts to move precision health into everyday healthcare.